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Public Library of Science, PLoS Neglected Tropical Diseases, 1(10), p. e0004304, 2016

DOI: 10.1371/journal.pntd.0004304

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Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B

Journal article published in 2016 by Gloria Morizot, Romain Jouffroy, Albert Faye, Paul Chabert, Katia Belhouari, Ruxandra Calin, Caroline Charlier, Patrick Miailhes, Jean-Yves Siriez, Oussama Mouri, Hélène Yera, Jacques Gilquin, Roland Tubiana, Fanny Lanternier, Marie-France Mamzer and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse events and resulted in rapid and sustained clinical and parasitological cure.