Identification of the students who are most likely to succeed in the nursing programmes has always remained an important goal of nursing schools and nurse educators. This study was conducted to identify predictors of academic performance of the students in the first year of basic nursing diploma programme in the province of Sindh, Pakistan. For this descriptive study, data was collected from Sindh Nurses Examination Board and all schools of nursing in province of Sindh. Multiple linear regression analysis method was used to develop regression model that identified predictor variable. Results indicated that academic factors including entry qualification, previous academic performance, and type of school are significantly related with the academic performance of the students. The study concluded that academic factors are better predictors of students' academic performance than the non-academic factors.