Elsevier, Current Opinion in Cell Biology, 6(22), p. 845-851, 2010
DOI: 10.1016/j.ceb.2010.08.002
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Many different signals for cell death converge on outer mitochondrial membrane permeabilization, a process controlled by the Bcl-2 family of proteins. Recent structural and biochemical analyses emphasize that key regulatory interactions between different classes of Bcl-2 family members occur at and in intracellular membranes, and insertion into membranes causes functionally important conformational changes in the proteins.