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Hindawi, Metal-Based Drugs, 5(7), p. 253-256, 2000

DOI: 10.1155/mbd.2000.253

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Comparative Analysis of [Au(en)2]3+ and [Pt(en)2]2+ non Covalent Binding to Calf Thymus DNA

Journal article published in 2000 by Giordana Marcon, T. OĆonnell, Tim O'Connell, Pierluigi Orioli, Luigi Messori ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Reactions of the complexes bisethylendiammine gold(III) and bisethylendiammine platinum(II) with calfthymus DNA were comparatively analysed. Both complexes bind DNA non-covalently most probably on the basis of electrostatic interactions. Binding of either complex at low ratios results into modest modifications of B-type DNA conformations, as detected by CD. Far larger CD alterations are observed at high ratios. The gold(III) chromophore is scarcely perturbed by DNA addition Binding of [Au(en)2]Cl3 to calf thymus DNA is reversed by sodium cyanide. By analogy with the case of [Pt(en)2]Cl2 it is suggested that Auen acts as a minor groove binder.