Changes in the severity of post-weaning multisystemic wasting syndrome (PMWS) and the effect of vaccination against porcine circovirus type 2 (PCV2) on the severity of PMWS and the prevalence of PCV2 were assessed on 50 English pig farms from 2008 to 2010. PMWS severity on farms before and after PCV2 vaccination was estimated by combining data on post-weaning mortality, morbidity and proportion of pigs positive for PCV2 by PCR. At the first visit (before vaccination), all 50 farms were seropositive for PCV2 and 90% of farms were positive for PCV2 by PCR. At the second visit (331-539days after the first visit), all 50 farms remained seropositive for PCV2 and 28/50 (56%) were positive for PCV2 by PCR, representing 16/36 (44.4%) farms that vaccinated against PCV2 and 12/14 (85.7%) farms that did not. There was a reduction of ∼50% in mean PMWS score on farms that vaccinated and were initially moderately or highly PMWS affected. Vaccination against PCV2 reduced the severity of PMWS, even though PCV2 persisted on 44% of farms after vaccination.