The October 2005 series of earthquakes that occurred in the Gulf of Siğaçik (western Turkey) reveal the operation of pure strike-slip faults, as evidenced from the 49 focal mechanisms we determined, in a region dominated by N–S extension and bounded by well-documented graben structures. The sequence is characterized by the occurrence of three moderate size events (17 October 2005, 05:45 UTC, Mw 5.4; 17 October 2005, 09:46 UTC, Mw 5.8; and 20 October 2005, 21:40 UTC, Mw 5.8) with an eastward propagation and close spatial separation (< 6 km). We relocated over 200 aftershocks, combining phases from the Greek and Turkish seismological networks, which align roughly in a NE–SW cloud, but considerably spread after the first day of the sequence, indicating the simultaneous activation of multiple structures nearly orthogonal to the main rupture. It is hard to relate the occurrence of the events to any of the previously mapped faults in the region. The region of occurrence is a well-known geothermal area which implies that it is in a very unstable state, with the fault systems close to rupture and very sensitive to stress perturbations. Here we showed that the sequence is adequately explained by static stress triggering. It is worth noting that this sequence, though moderate in magnitudes, provides stronger evidence for the operation of sub-parallel strike-slip faults in the central Aegean Sea–western Turkey, north of the volcanic arc, which seem to be optimally oriented in the regional stress field and facilitate the Anatolia motion into the Aegean Sea.