The use of an in vitro colony-forming assay has previously led to identification of a mesoderm-derived bipotent hemangioblast from differentiating hESCs. In this issue of Cell Stem Cell, Vodyanik et al. have used a similar approach to herald the presence of a bipotent mesoderm-derived precursor for mesenchymal stem and endothelial cells, termed the mesenchymoangioblast.