Published in

Karger Publishers, Respiration, 5(72), p. 512-516, 2005

DOI: 10.1159/000087676

Links

Tools

Export citation

Search in Google Scholar

The Effect of Red Cell Transfusion on Nitric Oxide Diffusing Capacity

Journal article published in 2005 by I. van der Lee, P. Zanen ORCID, D. H. Biesma, J. M. M. van den Bosch
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

<i>Background:</i> The diffusion capacity of the lung for nitric oxide (DL<sub>NO</sub>) is supposed to reflect the properties of the alveolocapillary membrane better than the diffusion capacity of the lung for carbon monoxide (DL<sub>CO</sub>), due to a much stronger binding of NO to haemoglobin (Hb). <i>Objectives:</i> The aim of this study was to investigate the effect of Hb concentration on the DL<sub>NO</sub>. <i>Methods:</i> The DL<sub>NO</sub> and DL<sub>CO</sub> (single-breath method) were measured in 10 anaemic patients before and shortly after red cell transfusion. <i>Results:</i> The mean increase in Hb concentration was 2.6 g/dl. Whereas DL<sub>CO</sub> increased as predicted by the reference equations, the DL<sub>NO</sub> did not change: mean DL<sub>CO</sub> rose from 13.6 to 16.5 ml/min/mm Hg (increase of 122%), mean DL<sub>CO</sub> corrected for Hb rose from 18.8 to 19.3 ml/min/mm Hg (103%) and mean DL<sub>NO</sub> rose from 75.6 to 77.8 ml/min/mm Hg (103%). <i>Conclusion:</i> The DL<sub>NO</sub> is not influenced by Hb concentration.