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Wiley-VCH Verlag, ChemInform, 28(46), p. no-no, 2015

DOI: 10.1002/chin.201528143

Royal Society of Chemistry, RSC Advances, 24(5), p. 18172-18176

DOI: 10.1039/c5ra01889g

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Domino transformation of isoxazoles to 2,4-dicarbonylpyrroles under Fe/Ni relay catalysis

Journal article published in 2015 by Ekaterina E. Galenko ORCID, Alexey V. Galenko, Alexander F. Khlebnikov, Mikhail S. Novikov
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The domino reaction of 5-alkoxy- or 5-aminoizoxazoles, under metal relay catalysis, with symmetric 1,3-diketones gives 4-acylpyrrole-2-carboxylic acid derivatives in high yield. Esters and amides of acylacetic acids react regioselectively, giving derivatives of pyrrole-2,4-dicarboxylic acid as the main products.