Published in
Public Library of Science, PLoS ONE, 8(6), p. e23604, 2011
DOI: 10.1371/journal.pone.0023604
Links
- ORCID
- Public Library of Science
- [www.ncbi.nlm.nih.gov] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [citeseerx.ist.psu.edu] | PDF
- [epub.ub.uni-muenchen.de] | PDF
- [europepmc.org] | PDF
Tools
Profiling Trait Anxiety: Transcriptome Analysis Reveals Cathepsin B (Ctsb) as a Novel Candidate Gene for Emotionality in Mice
,
Nafees Ahmad,
Mirjam Bunck,
Cornelia Graf,
Regina Widner,
Claudia Kühne,
Markus Panhuysen,
Boris Hambsch,
Gabriele Rieder
and other authors.
Full text: Download
Abstract
Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and physiological mechanisms. In this study, we aim to identify potential novel molecular targets that contribute to the multigenic trait “anxiety”. We used microarrays to investigate the gene expression profiles of different brain regions within the limbic system of mice which were selectively bred for either high (HAB) or low (LAB) anxiety-related behavior, and also show signs of comorbid depression-like behavior.