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BioMed Central, Gut Pathogens, 1(3), 2011

DOI: 10.1186/1757-4749-3-12

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Prevalence of aac(6')-Ib-cr plasmid-mediated and chromosome-encoded fluoroquinolone resistance in Enterobacteriaceae in Italy

Journal article published in 2011 by Ilaria Frasson, Antonietta Cavallaro, Cristina Bergo, Sara N. Richter ORCID, Giorgio Palù
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract The spread of aac(6')-Ib-cr plasmid-mediated quinolone resistance determinants was evaluated in 197 enterobacterial isolates recovered in an Italian teaching hospital. The aac(6')-Ib-cr gene was found exclusively in Escherichia coli strains. The gene was located on a plasmid which presented additional ESBL genes. Most of the clinical strains were clonally related and displayed three point mutations at the topoisomerase level which conferred high resistance to fluoroquinolones.