In recent years, there has been growing interest on the part of the remote sensing community in using the Antarctic area for calibrating and validating data of low-frequency satellite-borne microwave radiometers. In particular, the East Antarctic Plateau appears to be suited for this purpose. The reasons for this interest are the size, structure, spatial homogeneity, and thermal stability of this area. This is particularly interesting for low-frequency microwave radiometers since, due to the low extinction of dry snow, the upper ice-sheet layer is almost transparent and the brightness temperature variability is therefore extremely small. In the context of calibration and validation activities of the European Space Agency's Soil Moisture and Ocean Salinity (SMOS) satellite, an experiment called DOMEX-2, which included radiometric L-band measurements, was carried out at the Italian-French base of Concordia located at Dome C in the East Antarctic Plateau from December 2008 to December 2010. Ground measurements (i.e., snow temperature at different depths, snow structure, meteorological data, etc.) were also collected during the experiment. This paper presents information on the experimental campaign, the characteristics of the radiometric measurements, and the main results. A comparison with SMOS data is also presented.