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American Association for Cancer Research, Cancer Research, 16(68), p. 6482-6485, 2008

DOI: 10.1158/0008-5472.can-08-0044

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Tumors Sound the Alarmin(s)

Journal article published in 2008 by Seth B. Coffelt ORCID, Aline B. Scandurro
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins—including the defensins, LL-37, and HMGB1—in tumor development, progression, or suppression is discussed here. Taken together, these studies indicate that alarmins represent potential new targets for manipulation in a variety of tumors. [Cancer Res 2008;68(16):6482–5]