Published in
Nature Research, Nature Genetics, 7(40), p. 838-840, 2008
DOI: 10.1038/ng.163
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Common sequence variants on 20q11.22 confer melanoma susceptibility
Journal article published in 2008 by
Kevin M. Brown,
Stuart MacGregor,
Grant W. Montgomery,
David W. Craig,
Zhen Zhao,
Kelly Iyadurai,
Anjali K. Henders 
,
Anjali K. Henders,
Nils Homer,
Megan J. Campbell,
Mitchell Stark,
Shane Thomas,
Helen Schmid,
Elizabeth A. Holland,
Elizabeth M. Gillanders
and other authors.
,
Anjali K. Henders,
Nils Homer,
Megan J. Campbell,
Mitchell Stark,
Shane Thomas,
Helen Schmid,
Elizabeth A. Holland,
Elizabeth M. Gillanders
and other authors.
This paper is made freely available by the publisher.
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Abstract
We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.