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Taylor and Francis Group, RNA Biology, 5(11), p. 470-483

DOI: 10.4161/rna.28647

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Bioinformatics of prokaryotic RNAs

Journal article published in 2014 by Rolf Backofen, Fabian Amman, Fabrizio Costa, Sven Findeiß, Andreas S. Richter ORCID, Peter F. Stadler ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The genome of most prokaryotes gives rise to surprisingly complex transcriptomes, comprising not only protein-coding mRNAs, often organized as operons, but also harbors dozens or even hundreds of highly structured small regulatory RNAs and unexpectedly large levels of anti-sense transcripts. Comprehensive surveys of prokaryotic transcriptomes and the need to characterize also their non-coding components is heavily dependent on computational methods and workflows, many of which have been developed or at least adapted specifically for the use with bacterial and archaeal data. This review provides an overview on the state-of-the-art of RNA bioinformatics focusing on applications to prokaryotes.