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EMBO Press, EMBO Reports, 6(13), p. 501-514, 2012

DOI: 10.1038/embor.2012.55

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Losing balance: The origin and impact of aneuploidy in cancer

Journal article published in 2012 by Andrew J. Holland, Don W. Cleveland ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Most solid human tumours are aneuploid, that is, they contain an abnormal number of chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress response that suppresses cellular proliferation in vitro. Here, we review the progress in our understanding of the causes and effects of aneuploidy in cancer and discuss how, in specific contexts, aneuploidy can provide a growth advantage and facilitate cellular transformation. We also explore the emerging possibilities for targeting the cause or consequences of aneuploidy therapeutically.