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BMJ Publishing Group, Gut, 4(52), p. 496-501, 2003

DOI: 10.1136/gut.52.4.496

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Concomitant alterations in intragastric pH and ascorbic acid concentration in patients with Helicobacter pylori gastritis and associated iron deficiency anaemia

Journal article published in 2003 by G. Capurso ORCID, E. Lahner, S. Passi, R. Ricci, F. Maggio, G. Delle Fave, B. Annibale
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Seroepidemiological and clinical studies suggest that Helicobacter pylori may cause iron deficiency anaemia (IDA) in the absence of peptic lesions by undefined mechanisms, which still remain to be fully elucidated. Gastric acidity and ascorbic acid (AA) promote iron absorption. AA is lowered in the presence of H pylori infection. H pylori can cause atrophic body gastritis with achlorhydria, decreased iron absorption, and consequent IDA. Whether alterations in intragastric acidity and AA concentrations play a role in IDA developing in patients with H pylori gastritis remains to be determined.