Published in

Springer Nature [academic journals on nature.com], Cell Death and Disease, 1(5), p. e1018-e1018, 2014

DOI: 10.1038/cddis.2013.548

Links

Tools

Export citation

Search in Google Scholar

Clinical update on cancer: molecular oncology of head and neck cancer

Journal article published in 2014 by Y. Suh, I. Amelio ORCID, T. Guerrero Urbano, M. Tavassoli
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Head and neck cancers encompass a heterogeneous group of tumours that, in general, are biologically aggressive in nature. These cancers remain difficult to treat and treatment can cause severe, long-term side effects. For patients who are not cured by surgery and/or (chemo)radiotherapy, there are few effective treatment options. Targeted therapies and predictive biomarkers are urgently needed in order to improve the management and minimise the treatment toxicity, and to allow selection of patients who are likely to benefit from both nonselective and targeted therapies. This clinical update aims to provide an insight into the current understanding of the molecular pathogenesis of the disease, and explores the novel therapies under development and in clinical trials.