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Public Library of Science, PLoS ONE, 6(7), p. e39008, 2012

DOI: 10.1371/journal.pone.0039008

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Pulmonary Toxicity and Adjuvant Effect of Di-(2-exylhexyl) Phthalate in Ovalbumin-Immunized BALB/c Mice

Journal article published in 2012 by Jing Guo, Bing Han, Longjuan Qin, Bing Li, Huihui You, Jiwen Yang, Dandan Liu, Chenxi Wei, Eewa Nanberg, Carl-Gustaf Bornehag ORCID, Xu Yang
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Asthma is a complex pulmonary inflammatory disease, which is characterized by airway hyperresponsiveness, variable airflow obstruction and inflammation in the airways. The majority of asthma is allergic asthma, which is a disease caused by type I hypersensitivity mediated by IgE. Exposures to a number of environmental chemicals are suspected to lead to asthma, one such pollutant is di-(2-ethylheyl) phthalate (DEHP). DEHP is a manufactured chemical that is commonly added in plastic products to make them flexible. Epidemiological studies have revealed a positive association between DEHP exposure and asthma prevalence.