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Elsevier, Journal of the American College of Cardiology, 2(65), p. 163-173, 2015

DOI: 10.1016/j.jacc.2014.10.042

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Alterations in the Interactome of Serine/Threonine Protein Phosphatase Type-1 in Atrial Fibrillation Patients

Journal article published in 2015 by David Y. Chiang PhD ORCID, Nicolas Lebesgue, David L. Beavers PhD, Katherina M. Alsina Ba, Katherina M. Alsina, J. Mirjam A. Damen, Niels Voigt, J. Mirjam A. Damen BSc, Niels Voigt Md, Xander H. T. Wehrens, Dobromir Dobrev ORCID, Dobromir Dobrev Md, PhD Xander H. T. Wehrens Md, Arjen Scholten
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Abstract

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, yet current pharmacological treatments are limited. Serine/threonine protein phosphatase type-1 (PP1), a major phosphatase in the heart, consists of a catalytic subunit (PP1c) and a large set of regulatory (R)-subunits that confer localization and substrate specificity to the holoenzyme. Previous studies suggest that PP1 is dysregulated in AF, but the mechanisms are unknown.