In this chapter of Tools and Techniques Clinical, optimising stenting strategy in bifurcation lesions with insights from in vitro bifurcation models is discussed using a stepwise approach. The following is a summarised overview of this technique. The complete, unabridged version with images is available online at www.eurointervention.org bifurcation techniques. The switch to high-resolution three-dimensional quantitative imaging with microfocus CT and scanning electron microscopy now allows a detailed study of the impact of different stent designs and deployment techniques in a controlled and reproducible environment.