Dissemin is shutting down on January 1st, 2025

Published in

Elsevier, Neuroscience, (276), p. 148-160

DOI: 10.1016/j.neuroscience.2013.10.018

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White matter plasticity in adulthood

Journal article published in 2014 by Shiwei Wang, Kaylene M. Young ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Central nervous system (CNS) white matter is subject to a novel form of neural plasticity which has been termed "myelin plasticity". It is well established that oligodendrocyte generation and the addition of new myelin internodes continue throughout normal adulthood. These new myelin internodes maybe required for the de novo myelination of previously unmyelinated axons, myelin sheath replacement, or even myelin remodelling. Each process could alter axonal conduction velocity, but to what end? We review the changes that occur within the white matter over the lifetime, the known regulators and mediators of white matter plasticity in the mature CNS, and the physiological role this plasticity may play in CNS function.