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American Society of Tropical Medicine and Hygiene, American Journal of Tropical Medicine and Hygiene, 6(90), p. 1156-1158, 2014

DOI: 10.4269/ajtmh.14-0029

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Antischistosomal versus Antiandrogenic Properties of Aryl Hydantoin Ro 13-3978

Journal article published in 2014 by Chunkai Wang, Jaeki Min, Xiaofang Wang, Sakthivel Muniyan, Yuxiang Dong, Qingjie Zhao, Mireille Vargas, R. Kiplin Guy, Jonathan L. Vennerstrom, Ming-Fong Lin, R. Kiplin Guy ORCID, Jennifer Keiser
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In the early 1980s, the antischistosomal aryl hydantoin Ro 13-3978 (AH01), a close structural analogue of the androgen receptor antagonist nilutamide, was discovered. Administration of 100 mg/kg oral doses of AH01 to mice infected with adult and juvenile Schistosoma mansoni produced 95% and 64% total worm burden reductions, confirming its high activity against adult worms, and showing that AH01 is also effective against juvenile infections. The AH01 had no measureable interaction with the androgen receptor in a ligand competition assay, but it did block dihydrotestosterone-induced cell proliferation in an androgen-dependent human prostate cancer cell line. For AH01, nilutamide, and three closely related aryl hydantoin derivatives, there was no correlation between antischistosomal activity and androgen receptor interaction.