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Elsevier, Nuclear Medicine and Biology, 2(43), p. 131-139, 2016

DOI: 10.1016/j.nucmedbio.2015.11.003

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Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates

Journal article published in 2016 by Hongjun Jin, Xiang Zhang, Xuyi Yue ORCID, Hui Liu ORCID, Junfeng Li, Hao Yang, Hubert Flores, Yi Su, Stanley M. Parsons, Joel S. Perlmutter, Zhude Tu ORCID
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This paper is available in a repository.

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Abstract

Deficits in cholinergic function have been found in the aged brain and in neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD). The vesicular acetylcholine transporter (VAChT) is a reliable biomarker for the cholinergic system. We previously reported the initial in vitro and ex vivo characterization of (−)-[11C]TZ659 as a VAChT specific ligand. Here, we report the in vivo specificity, tracer kinetics, and dose-occupancy studies in the nonhuman primate brain.