Published in
Elsevier, Molecular and Cellular Proteomics, 6(13), p. 1495-1509, 2014
Links
- ORCID
- ORCID
- Elsevier
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Quantitative Chemical Proteomics Identifies Novel Targets of the Anti-cancer Multi-kinase Inhibitor E-3810*
Journal article published in 2014 by
Mara Colzani 
,
Roberta Noberini,
Mauro Romanenghi,
Gennaro Colella,
Maurizio Pasi,
Daniele Fancelli,
Mario Varasi,
Saverio Minucci,
Tiziana Bonaldi
,
Roberta Noberini,
Mauro Romanenghi,
Gennaro Colella,
Maurizio Pasi,
Daniele Fancelli,
Mario Varasi,
Saverio Minucci,
Tiziana Bonaldi
This paper is made freely available by the publisher.
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Abstract
Novel drugs are designed against specific molecular targets, but almost unavoidably they bind non-targets, which can cause additional biological effects that may result in increased activity or, more frequently, undesired toxicity. Chemical proteomics is an ideal approach for the systematic identification of drug targets and off-targets, allowing unbiased screening of candidate interactors in their natural context (tissue or cell extracts).