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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 5(51), p. 1844-1848, 2007

DOI: 10.1128/aac.01428-06

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In Vitro Bactericidal Activity of the Antiprotozoal Drug Miltefosine against Streptococcus pneumoniae and Other Pathogenic Streptococci

Journal article published in 2007 by Daniel Llull, Luis Rivas ORCID, Ernesto García
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Miltefosine (hexadecylphosphocholine), the first oral drug against visceral leishmaniasis, triggered pneumococcal autolysis at concentrations higher than 2.5 μM. Bactericidal activity was also observed in cultures of other streptococci, although these failed to undergo lysis. The autolysis elicited by miltefosine can be attributed to triggering of the pneumococcal autolysin LytA.