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Elsevier, Microbes and Infection, 4(14), p. 341-347, 2012
DOI: 10.1016/j.micinf.2011.11.008
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A regulatory instead of an IL-17 T response predominates in Helicobacter pylori-associated gastritis in children
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Andreia Maria Camargos Rocha,
Fabrício Freire de Melo,
Gifone Aguiar Rocha,
Silvia Helena Sousa Pietra Pedroso,
Sérgio de Assis Batista,
Lúcia Porto Fonseca de Castro,
Lúcia Porto Fonseca de Castro,
Simone Diniz Carvalho,
Paulo Fernando Souto Bittencourt,
Celso Afonso de Oliveira,
Dulciene Maria Magalhães Queiroz,
Dulciene Maria Magalhães Queiroz ,
Rodrigo Corrêa-Oliveira
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Abstract
Th17 cells seem to have an important role in the efficacy of vaccines against Helicobacter pylori. Because children are a target group for human vaccination and Th17/T(reg) cells have intrinsically linked and antagonic commitments, we compared the gastric levels of Th17- and T(reg)-associated cytokines of children and adults. IL-6, IL-10 and TGF-β1 levels and Foxp3(+) cell numbers were higher, but IL-1β, IL-17A and IL-23 were lower in infected children than in infected adults. In conclusion T(reg) instead of Th17 cell response to H. pylori-infection predominates in children.