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National Academy of Sciences, Proceedings of the National Academy of Sciences, 17(100), p. 9873-9877, 2003

DOI: 10.1073/pnas.1734000100

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A SNARE required for retrograde transport to the endoplasmic reticulum

Journal article published in 2003 by Lena Burri, Oleg Varlamov, Claudia A. Doege, Kay Hofmann, Traude Beilharz, James E. Rothman, Thomas H. Söllner, Trevor Lithgow
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

SNAREs (soluble N -ethylmaleimide-sensitive factor attachment protein receptors) are central components of the machinery mediating membrane fusion in all eukaryotic cells. Sequence analysis of the yeast genome revealed a previously uncharacterized SNARE, S NARE- l ike t ail-anchored protein 1 (Slt1). Slt1 is an essential protein localized in the endoplasmic reticulum (ER). It forms a SNARE complex with Sec22 and the ER syntaxin Ufe1. Down-regulation of Slt1 levels leads to improper secretion of proteins normally resident in the ER. We suggest that Slt1 is a component of the SNAREpin required for retrograde traffic to the ER. Based on the previously reported association with Ufe1 and Sec22, Sec20 likely contributes the fourth SNARE to the SNAREpin.