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American Society for Clinical Investigation, Journal of Clinical Investigation, 6(117), p. 1477-1480, 2007

DOI: 10.1172/jci32518

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Vascular biology and bone formation: hints from HIF

Journal article published in 2007 by Dwight A. Towler ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In this issue of the JCI, Wang, Clemens, and colleagues demonstrate that hypoxia-inducible factor alpha (HIF alpha) signaling in bone-building osteoblasts is central to the coupling of angiogenesis and long bone development in mice (see the related article beginning on page 1616). They show that bone formation controlled by osteoblast HIF alpha signaling is not cell autonomous but is coupled to skeletal angiogenesis dependent upon VEGF signaling. Thus, strategies that promote HIF alpha signaling in osteoblasts may augment bone formation and accelerate fracture repair.