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American Chemical Society, Journal of the American Chemical Society, 28(129), p. 8710-8711, 2007

DOI: 10.1021/ja073055a

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Aspartate-Catalyzed Asymmetric Epoxidation Reactions

Journal article published in 2007 by Gorka Peris, Charles E. Jakobsche, Scott J. Miller ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We report enantioselective epoxidation reactions that are catalyzed by aspartic acid-containing peptides. The strategy involves the transient conversion of the aspartate carboxylic acid side chain to the corresponding peracid. Reaction of olefin with the activated catalyst regenerates that catalyst, which may be subjected to multiple turnovers through a carbodiimide-mediated dehydration pathway. Enantioselectivities of up to 92% ee are observed for a class of urethane-substituted olefins.