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American Chemical Society, ACS Chemical Neuroscience, 4(5), p. 261-265, 2014

DOI: 10.1021/cn400222s

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Neoglucosylated Collagen Matrices Drive Neuronal Cells to Differentiate

Journal article published in 2014 by Laura Russo ORCID, Antonella Sgambato, Marzia Lecchi, Valentina Pastori, Mario Raspanti, Antonino Natalello ORCID, Silvia Maria Doglia, Francesco Nicotra, Laura Cipolla
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Despite the relevance of carbohydrates as cues in eliciting specific biological responses, glycans have been rarely exploited in the study of neuronal physiology. We report thereby the study of the effect of neoglucosylated collagen matrices on neuroblastoma F11 cell line behaviour. Morphological and functional analysis clearly showed that neoglucosylated collagen matrices were able to drive cells to differentiate. These data show for the first time that F11 cells can be driven from proliferation to differentiation without the use of chemical differentiating agents. Our work may offer to cell biologists new opportunities to study neuronal cell differentiation mechanisms in a cell environment closer to physiological conditions.