Water, being a primary element in the diet and a necessary resource for the agriculture, can be considered a basic need for humans. In addition, also industrial practices need a growing amount of water. Since human population is continuously growing at a rate that, in the last two centuries, approximates well the exponential, water demand is increasing. However, the water resources on the Earth are finite. For this reason, even disregarding the potential threats due to the climate change, this situation appears as one of the biggest challenges of the current era. Actually, several small-scale regions already face water sustainability problems, and the scarcity of water resources is expected to spread to wider areas in the near future, if the actual trends of development and population growth do not change. The situation is exacerbated as the climate is already changing, due to the anthropogenic emissions of greenhouse gases in the atmosphere, and its rate is expected to increase by the end of this century. The effects of these changes will increase the natural variability of the climate, exacerbating the extreme climatic phenomena (drought and flood events) and increasing the difficulty of managing water resources, especially in the most vulnerable regions.