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Elsevier, Journal of Biological Chemistry, 23(288), p. 16557-16566, 2013

DOI: 10.1074/jbc.m113.458729

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A Molecular Mechanism for Therapeutic Effects of cGMP-elevating Agents in Pulmonary Arterial Hypertension*

Journal article published in 2013 by Raphaela Schwappacher, Ana Kilic, Baktybek Kojonazarov, Michaela Lang, Thuan Diep, Shunhui Zhuang, Thomas Gawlowski, Ralph T. Schermuly ORCID, Alexander Pfeifer, Gerry R. Boss, Renate B. Pilz
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Pulmonary arterial hypertension (PAH) is characterized by abnormal vascular remodeling and impaired BMP/Smad signaling.