In this paper, we propose new mathematical models with nonlinear incidence rate and double epidemic hypothesis. Then we dedicate to develop a method to obtain the threshold of the stochastic SIS epidemic model. To this end, first, we investigate the stability of the equilibria of the deterministic system and obtain the conditions for the extinction and the permanence of two epidemic diseases. Second, we explore and obtain the threshold of a stochastic SIS system for the extinction and the permanence in mean of two epidemic diseases. The results show that a large stochastic disturbance can cause infectious diseases to go to extinction, in other words, the persistent infectious disease of a deterministic system can become extinct due to the white noise stochastic disturbance. This implies that the stochastic disturbance is conducive to epidemic diseases control. To illustrate the performance of the theoretical results, we present a series of numerical simulations of these cases with respect to different noise disturbance coefficients.