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Taylor and Francis Group, OncoImmunology, 12(4), p. e1053684

DOI: 10.1080/2162402x.2015.1053684

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CAR-T cells are serial killers

Journal article published in 2015 by Alexander J. Davenport, Misty R. Jenkins ORCID, David S. Ritchie, H. Miles Prince, Joseph A. Trapani ORCID, Michael H. Kershaw, Phillip K. Darcy, Paul J. Neeson
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Chimeric Antigen Receptor (CAR) T cells have enjoyed unprecedented clinical success for haematological malignancies in recent years. However several aspects of CAR T cell biology remain unknown. We compared CAR and TCR killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained over the long term due to CAR down-regulation after 20 hours.