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Beilstein-Institut, Beilstein Journal of Organic Chemistry, (8), p. 753-762, 2012

DOI: 10.3762/bjoc.8.86

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Formation of carbohydrate-functionalised polystyrene and glass slides and their analysis by MALDI-TOF MS

Journal article published in 2012 by Martin J. Weissenborn, Johannes W. Wehner, Robert Sardzik, Robert Šardzík, Wehner JW Gray CJ Šardzík R Eyers CE* Lindhorst TK* and Flitsch Sl*. Weissenborn Mj, Christopher J. Gray, Claire E. Eyers ORCID, Thisbe K. Lindhorst, Sabine L. Flitsch ORCID, Johannes W. Wehner Christopher J. Gray Robert Šardzík Claire E. Eyers Thisbe K. Lindhorst and Sabine L. Flitsch Martin J. Weissenborn
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Glycans functionalised with hydrophobic trityl groups were synthesised and adsorbed onto polystyrene and glass slides in an array format. The adsorbed glycans could be analysed directly on these minimally conducting surfaces by MALDI-TOF mass spectrome-try analysis after aluminium tape was attached to the underside of the slides. Furthermore, the trityl group appeared to act as an internal matrix and no additional matrix was necessary for the MS analysis. Thus, trityl groups can be used as simple hydrophobic, noncovalently linked anchors for ligands on surfaces and at the same time facilitate the in situ mass spectrometric analysis of such ligands.