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Public Library of Science, PLoS ONE, 6(7), p. e36691, 2012

DOI: 10.1371/journal.pone.0036691

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Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds

Journal article published in 2012 by Ute Philipp, Andrea Vollmar, Jens Häggström ORCID, Anne Thomas, Ottmar Distl
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Dilated cardiomyopathy (DCM) is a highly prevalent and often lethal disease in Irish wolfhounds. Complex segregation analysis indicated different loci involved in pathogenesis. Linear fixed and mixed models were used for the genome-wide association study. Using 106 DCM cases and 84 controls we identified one SNP significantly associated with DCM on CFA37 and five SNPs suggestively associated with DCM on CFA1, 10, 15, 21 and 17. On CFA37 MOGAT1 and ACSL3 two enzymes of the lipid metabolism were located near the identified SNP.