Published in
Elsevier, Journal of Clinical Virology, 4(61), p. 615-616
DOI: 10.1016/j.jcv.2014.09.020
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The saliva quantitative PCR assay is inadequate to detect and monitor human herpesvirus-7 and -6 reactivation in patients with Pityriasis rosea
Journal article published in 2014 by
Francesco Broccolo 
,
Giulia Ciccarese ,
Massimo Oggioni,
Alfredo Rebora,
Aurora Parodi,
Francesco Drago
,
Giulia Ciccarese ,
Massimo Oggioni,
Alfredo Rebora,
Aurora Parodi,
Francesco Drago
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Abstract
The endogenous reactivation of HHV-6/7 may result in Pityriasis rosea (PR). The blood viral load distinguishes between latent and clinically manifest disease. We compared HHV-7/6 DNA load in saliva and blood samples of PR patients and controls. Salivary PCR assay is inadequate to detect and follow-up HHV-7 reactivation in PR. Only the plasma viral DNA load remains the direct marker of the viral replication.