Published in
Taylor and Francis Group, Bioscience, Biotechnology and Biochemistry, 6(77), p. 1296-1298, 2013
DOI: 10.1271/bbb.120944
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Styrene Altered Clock Gene Expression in Serum-Shocked Cultured Human Fibroblasts
,
Sara Staffolani,
Elisabetta Strafella,
Venerando Rapisarda,
Matteo Valentino,
Monica Amati,
Alfredo Copertaro,
Lory Santarelli
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Abstract
The circadian clock can regulate the metabolic process of xenobiotics, but little is known as to circadian rhythms can be perturbed by xenobiotics. Styrene is a organic chemical widely used in occupational settings. The effects of styrene on the circadian genes of HuDE cells were evaluated after serum-shocking synchronization. A subtoxic dose of 100 µM of styrene altered the expression of clock genes BMAL1, PER2, PER3, CRY1, CRY2, and REV-ERB-α.