Published in

American Society for Microbiology, Journal of Virology, 7(89), p. 4023-4029, 2015

DOI: 10.1128/jvi.02946-14

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Requirement for Chloride Channel Function during the Hepatitis C Virus Life Cycle

Journal article published in 2015 by Bjorn-Patrick Mohl, Jonathan D. Lippiat ORCID, Jamel Mankouri, Zsofia Igloi ORCID, Mark Harris
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Hepatocytes express an array of plasma membrane and intracellular ion channels, yet their role during the hepatitis C virus (HCV) life cycle remains largely undefined. Here, we show that HCV increases intracellular hepatic chloride (Cl − ) influx that can be inhibited by selective Cl − channel blockers. Through pharmacological and small interfering RNA (siRNA)-mediated silencing, we demonstrate that Cl − channel inhibition is detrimental to HCV replication. This represents the first observation of the involvement of Cl − channels during the HCV life cycle.