Honeybees are social insects of considerable ecological and economic importance and, therefore, the preservation of their health became an important topic of research worldwide. Until now, no treatment is available as a preventive agent of honeybee viral diseases that can cause significant colony losses. Here, we propose a model system for screening antivirals among plant extracts using forager honeybees naturally infected with Black Queen Cell Virus (BQCV). BQCV is the most prevalent virus that persists as a covert infection in honeybees. This positive-sense ssRNA virus belongs to the well-known Dicistroviridae family, sharing common features with hepatitis C virus. We developed studies on the antiviral role of European propolis (bee glue, plant resins) and Artemisia absinthium, Laurus nobilis leaf extracts that are rich in bioactive compounds and were proven to have antiviral activities in other systems. Among the tested extracts, the Artemisia extract did not show any antiviral effect and propolis extracts showed only a weak trend in the reduction of the virus. Just the Laurus extract led to a significant decrease of virus replication and overall virus titer in forager honeybees. We conclude that using our newly developed BQCV infection-forager bee assay is a time saving and stress reducing approach for bees that can be applied up to a medium and high-throughput screening model system for antiviral drugs under natural conditions. Moreover, using insects as model system brings valuable information regarding the impact of different xenobiotics on a living organism.