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Hindawi, Journal of Nucleic Acids, (2011), p. 1-6, 2011

DOI: 10.4061/2011/756905

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Validation of a Diagnostic Microarray for Human Papillomavirus: Coverage of 102 Genotypes

Journal article published in 2011 by Sarah Tuttleton Arron, Peter Skewes-Cox ORCID, Phong H. Do, Eric Dybbro, Maria Da Costa, Joel M. Palefsky, Joseph L. DeRisi
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Papillomaviruses have been implicated in a variety of human diseases ranging from common warts to invasive carcinoma of the anogenital mucosa. Existing assays for genotyping human papillomavirus are restricted to a small number of types. Here, we present a comprehensive, accurate microarray strategy for detection and genotyping of 102 human papillomavirus types and validate its use in a panel of 91 anal swabs. This array has equal performance to traditional dot blot analysis with the benefits of added genotype coverage and the ability to calibrate readout over a range of sensitivity or specificity values.