Published in
American Chemical Society, Organic Letters, 18(17), p. 4510-4513, 2015
DOI: 10.1021/acs.orglett.5b02184
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In Situ Generated Fluorinated Iminium Salts for Difluoromethylation and Difluoroacetylation
Journal article published in 2015 by
Etienne Schmitt,
Baptiste Rugeri,
Armen Panossian,
Jean-Pierre Vors,
Sergii Pazenok,
Frédéric R. Leroux 
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Abstract
The use of TFEDMA, a fluoroalkyl amino reagent, for the difluoromethylation and difluoroacylation of arenes, heteroarenes, and C-H acidic compounds is reported. This approach allows for an efficient access to difluoromethylated products of high added value in good to excellent yields and with scale-up possibilities.