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Georg Thieme Verlag, Planta Medica: Journal of Medicinal Plant and Natural Product Research, 12(68), p. 1055-1058

DOI: 10.1055/s-2002-36360

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Inhibition of Cytochrome P450 3A4 by Extracts and Kavalactones ofPiper methysticum(Kava-Kava)

Journal article published in 2002 by Matthias Unger, Ulrike Holzgrabe, Wolfgang Jacobsen, Carolyn Cummins ORCID, Leslie Z. Benet
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Inhibitors of cytochrome P450 3A4 (CYP3A4) were identified in crude extracts from the rhizomes of Piper methysticum G. Forst. (Kava-Kava) using bioassay-guided fractionation. After preliminary purification of an ethyl acetate extract with solid phase extraction, the eluate was further fractionated by means of HPLC and fractions were tested for inhibitory potency using cDNA expressed CYP3A4. Positive fractions were analysed with LC/MS using electrospray ionisation and kavapyrones could be identified as the main CYP3A4 inhibitory components of Piper methysticum.