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Elsevier, Materials Science and Engineering: C, (58), p. 264-272

DOI: 10.1016/j.msec.2015.08.047

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Evaluation of cystamine-modified hyaluronic acid/chitosan polyplex as retinal gene vector

Journal article published in 2016 by Ana V. Oliveira ORCID, Adriana Marcelo ORCID, Ana M. Rosa da Costa, Ana M. Rosa da Costa, Gabriela A. Silva
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A successful gene therapy approach can prevent or treat congenital and acquired diseases. However, there is still no ideal non-viral vector for gene delivery in a safe and timely manner. In this report the anionic polymer hyaluronic acid (HA) was investigated as a potential vector for gene therapy. Due to its intrinsic characteristics it constitutes an excellent candidate to deliver therapeutic genes, pending the modification of its surface charge.