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Springer, Bulletin of Experimental Biology and Medicine, 5(158), p. 607-610, 2015

DOI: 10.1007/s10517-015-2817-9

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Behavioral, Hormonal, and Neurotransmitter Reactions to Stress in Adult Rats with a History of High IL-1β Content in the Early Postnatal Ontogeny

Journal article published in 2015 by O. E. Zubareva ORCID, A. P. Schwartz, L. K. Khnychenko, A. M. Ishchenko, A. S. Simbirtsev, V. M. Klimenko
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Behavioral, hormonal, and neurotransmitter reactions to foot shock were studied in adult rats treated with IL-1β during week 3 of life. After stress, these animals differed from controls treated with saline by high levels of dopamine, serotonin, and 5-hydroxy-indolacetic acid in the hypothalamus. In contrast to controls, they developed a significant stress-induced increase of blood corticosterone level and exhibited lesser motor and exploratory activities in the open field test.