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Elsevier, Journal of the American College of Cardiology, 1(45), p. 35-42, 2005

DOI: 10.1016/j.jacc.2004.09.047

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CD40 ligand enhances monocyte tissue factor expression and thrombin generation via oxidative stress in patients with hypercholesterolemia

Journal article published in 2005 by Valerio Sanguigni, Domenico Ferro, Pasquale Pignatelli, Maria Del Ben, Tini Nadia, Mirella Saliola, Roberto Sorge, Francesco Violi ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

OBJECTIVES We tested the hypothesis that CD40 ligand (CD40L) induces a prothrombotic state by enhancing oxidative stress. BACKGROUND Patients with hypercholesterolemia show an ongoing prothrombotic state, but the underlying mechanism is still unclear. METHODS Circulating levels of the soluble form of CD40L (sCD40L), prothrombin fragment (F1+2, a marker of thrombin generation), and 8-hydroxy-2'-deoxyguanosine (8-OHdG, a marker of oxidative stress) were measured in 40 patients with hypercholesterolemia and in 20 age- and gender-matched healthy subjects. RESULTS Patients with hypercholesterolemia showed significantly higher levels of sCD40L (p