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Oxford University Press, The Journal of Clinical Endocrinology & Metabolism, 4(98), p. 1711-1717, 2013

DOI: 10.1210/jc.2012-3931

SAGE Publications, Annals of Clinical Biochemistry, 4(50), p. 388-389, 2013

DOI: 10.1177/0004563213488059a

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Influence of Vitamin D Status on Vertebral Fractures, Bone Mineral Density, and Bone Turnover Markers in Normocalcemic Postmenopausal Women With High Parathyroid Hormone Levels

Journal article published in 2013 by José L. Hernández ORCID, José M. Olmos Martínez, C. Parker, Daniel Nan, Carmen Valero, Josefina Martínez, Javier Llorca, Emilio Pariente Rodrigo ORCID, Eduardo Obregón, Jesús González-Macías
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Objective: The aims of the study were to analyze whether there is an association between serum PTH and the prevalence of vertebral fractures and its possible dependence on vitamin D status, and to assess the influence of serum 25-hydroxyvitamin D (25OHD) in the relationship between PTH and bone mineral density (BMD) or bone turnover markers (BTMs). Design, Participants, and Setting: A total of 820 postmenopausal women were recruited after excluding those with any known condition that could influence serum PTH levels, except for a possible low serum 25OHD. Serum PTH and 25OHD concentrations, as well as vertebral fracture prevalence, BMD, and BTM (CTX and PINP) values were recorded. Serum PTH levels were divided into tertiles, and women were grouped into those in the highest tertile (58 pg/ml) and those below. Serum 25OHD levels were stratified in 3 categories (20, 20 –30, and 30 ng/ml).