Published in

Elsevier, Experimental and Molecular Pathology, 2(85), p. 77-82, 2008

DOI: 10.1016/j.yexmp.2008.07.004

Links

Tools

Export citation

Search in Google Scholar

Cataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRT1-14

Journal article published in 2008 by Shinje Ghim, A. Bennett Jenson, A. Bennett Jenson, Jason A. Bubier ORCID, Kathleen A. Silva, Richard S. Smith, John P. Sundberg
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Human papillomavirus type 18 (HPV18) is a common cause of cervical cancer. To create a mouse model for this common neoplastic disease, we used a human keratin 14 promoter to drive the HPV18 E7 oncogene to create transgenic mice. No mice up to a year of age developed cervical cancer. However, all transgenic mice and none of the controls developed progressive bilateral cortical cataracts. By 6 months of age, the cortex liquefied leaving the lens nucleus. Proliferation of lens epithelium formed multifocal nodules and free floating lens epithelial cells within the liquefied cortex. These cells were hyperplastic not neoplastic. Other HPV transgenic stocks develop cataracts suggesting this virus may have a broad cellular tropism.