To support the forecasting needs of the United States Antarctic Program at McMurdo, Antarctica, a special numerical weather prediction program, the Antarctic Mesoscale Prediction System (AMPS), was established for the 2000-01 field season. AMPS employs the Polar MM5, a version of the fifth-generation Pennsylvania State University-NCAR Mesoscale Model (MM5) that has physics modifications for polar environments. This study assesses the performance of AMPS in forecasting an event of mesoscale cyclogenesis in the western Ross Sea during 13-17 January 2001. Observations indicate the presence of a complex trough having two primary me- soscale lows that merge to the east of Ross Island shortly after 0700 UTC 15 January. In contrast, AMPS predicts one primary mesoscale low throughout the event, incorrectly placing it until the 1800 UTC 15 January forecast, when the observed system carries a prominent signature in the initialization. The model reproduces the evolution of upper-level conditions in agreement with the observations and shows skill in resolving many small-scale surface features common to the region (i.e., katabatic winds; lows and highs induced by wind/topography). The AMPS forecasts can rely heavily on the representation of surface lows and upper-level forcing in the first-guess fields derived from NCEP's Aviation Model (AVN). Furthermore, even with relatively high spatial resolution, mesoscale models face observation-related limitations on performance that can be particularly acute in Antarctica.